Determination of beta-defensin genomic copy number in different populations: a comparison of three methods
Research output: Contribution to journal › Journal article › Research › peer-review
There have been conflicting reports in the literature on association of gene copy number with disease, including CCL3L1 and HIV susceptibility, and ß-defensins and Crohn's disease. Quantification of precise gene copy numbers is important in order to define any association of gene copy number with disease. At present, real-time quantitative PCR (QPCR) is the most commonly used method to determine gene copy number, however the Paralogue Ratio Test (PRT) is being used in more and more laboratories.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 6 |
| Issue number | 2 |
| Pages (from-to) | e16768 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 2011 |
- Base Sequence, Chromosome Mapping, Cohort Studies, Czech Republic, Denmark, Gene Dosage, Genetic Predisposition to Disease, Genetics, Population, Genome, Human, Ghana, Great Britain, Humans, Molecular Sequence Data, Population, Portugal, beta-Defensins
Research areas
ID: 40245792