Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.
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To investigate the function of the laminin alpha5-chain, previously identified in mice, cDNA clones encoding the 953-amino-acid carboxy terminal G-domain of the human laminin alpha5-chain were characterized. Northern blot analysis showed that the laminin alpha5-chain is expressed in human placenta, heart, lung, skeletal muscle, kidney, and pancreas. The human laminin alpha5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.
| Original language | English |
|---|---|
| Journal | FEBS Letters |
| Volume | 411 |
| Issue number | 2-3 |
| Pages (from-to) | 296-300 |
| Number of pages | 4 |
| ISSN | 0014-5793 |
| Publication status | Published - 1997 |
Bibliographical note
Keywords: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 20; Cloning, Molecular; Gene Expression Regulation; Humans; In Situ Hybridization; Laminin; Linkage (Genetics); Mice; Molecular Sequence Data; Mutation; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid
ID: 5236642