Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review
Research output: Contribution to journal › Review › peer-review
Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
Original language | English |
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Journal | Journal of Cardiovascular Translational Research |
Volume | 7 |
Issue number | 6 |
Pages (from-to) | 570-580 |
Number of pages | 11 |
ISSN | 1937-5387 |
DOIs | |
Publication status | Published - Aug 2014 |
- Animals, Cardiovascular Agents, Disease Models, Animal, Myocardial Reperfusion Injury, Swine, Treatment Outcome
Research areas
ID: 138137612