The influence of contrast media on kidney function in patients with stable coronary artery disease
Research output: Contribution to journal › Journal article › Research › peer-review
AIMS: To investigate the incidence of contrast media-induced nephropathy (CIN) in patients with stable coronary artery disease (CAD) referred for elective coronary intervention following hydration routines. The reversibility of CIN was followed in a 6 month-period.
METHODS AND RESULTS: A total of 447 patients referred for elective coronary intervention due to suspected CAD were included. Blood samples were collected before and 24 h after intervention and medical records were obtained. Patients had no drinking fluid restrictions and were routinely treated with a 1000 ml saline infusion. All patients were invited to a 6-month examination and collection of blood samples.
RESULTS: A total of 19 patients (4.3%) developed CIN. CIN patients had a pre-investigation higher estimated glomerular filtration rate (eGRF), lower level of kidney failure and lower creatinine level than non-CIN patients. Kidney function was not normalized in CIN patients 6 months after the intervention. Two patients still met the definition of CIN.
CONCLUSION: With no restriction in fluid intake and supplementary infusion of saline, only a few patients with stable CAD developed early indications of CIN during elective coronary interventions. Kidney function and the amount of contrast media used was not a predictor of CIN development. The induced CIN was not completely normalized in a 6-month follow-up period.
Original language | English |
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Journal | Scandinavian Cardiovascular Journal |
Volume | 48 |
Issue number | 4 |
Pages (from-to) | 234-240 |
Number of pages | 7 |
ISSN | 1401-7431 |
DOIs | |
Publication status | Published - Aug 2014 |
- Aged, Biological Markers, Contrast Media, Coronary Angiography, Coronary Artery Disease, Creatinine, Female, Fluid Therapy, Glomerular Filtration Rate, Humans, Kidney, Kidney Diseases, Male, Middle Aged, Percutaneous Coronary Intervention, Prospective Studies, Radiography, Interventional, Risk Factors, Time Factors, Treatment Outcome
Research areas
ID: 138181639