Study of medication-free children with Tourette syndrome do not show imaging abnormalities
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico-striato-thalamic-cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.
METHODS: This study was designed to investigate changes in gray and white matter in medication-free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.
RESULTS AND CONCLUSION: Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well-defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS.
Original language | English |
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Journal | Movement Disorders |
Volume | 29 |
Issue number | 9 |
Pages (from-to) | 1212-1216 |
Number of pages | 5 |
ISSN | 0885-3185 |
DOIs | |
Publication status | Published - Aug 2014 |
- Brain, Brain Mapping, Case-Control Studies, Child, Corpus Callosum, Diffusion Tensor Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Tourette Syndrome
Research areas
ID: 138376689