Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens

Research output: Contribution to journalJournal articlepeer-review

In areas of intense Plasmodium falciparum transmission, protective immunity is acquired during childhood in parallel with acquisition of agglutinating antibodies to parasite-encoded variant surface antigens (VSA) expressed on parasitized red blood cells. In a semi-immune child in such an area, clinical disease is caused mainly by parasites expressing VSA not recognized by preexisting VSA-specific antibodies in that child. Such malaria episodes are known to cause an increase in agglutinating antibodies specifically recognizing VSA expressed by the parasite isolate causing the illness, whereas antibody responses to other parasite isolates are relatively unaffected. However, the detailed kinetics of this VSA antibody acquisition are unknown and hence were the aim of this study. We show that P. falciparum malaria in Ghanaian children generally caused a rapid and sustained increase in variant-specific VSA antibody levels, while more transient and limited increases in levels of antibodies to VSA expressed by other parasite isolates were also seen. Plasma VSA antibody levels were positively correlated with the age of the healthy plasma donors but negatively correlated with the age of the parasite donors (the malaria patient). The data from this first detailed longitudinal study of acquisition of VSA antibodies support the hypothesis that naturally acquired protective immunity to P. falciparum malaria is mediated, at least in part, by VSA-specific antibodies.
Original languageEnglish
JournalInfection and Immunity
Volume70
Issue number6
Pages (from-to)2982-8
Number of pages6
ISSN0019-9567
DOIs
Publication statusPublished - 2002

Bibliographical note

Keywords: Aging; Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Antigens, Surface; Child; Child, Preschool; Genotype; Ghana; Humans; Infant; Longitudinal Studies; Malaria, Falciparum; Plasmodium falciparum; Population Surveillance; Seasons

ID: 5832069