Serum YKL-40 and uterine artery Doppler – a prospective cohort study, with focus on preeclampsia and small-for-gestational-age
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OBJECTIVE: To test if serum YKL-40 is increased in women developing preeclampsia or small-for-gestational age fetuses. We also assessed the association between uterine artery pulsatility index, notching and serum YKL-40 levels.
DESIGN: Prospective cohort study.
SETTING: A primary referral unit for obstetric ultrasound.
POPULATION: A total of 1214 unselected pregnant women enrolled at nuchal translucency examination between 11(+3) and 13(+6) weeks of gestation.
METHODS: All women had ultrasound and blood sample collection at the nuchal translucency scan, a 20-week malformation scan and 25-week and 32-week fetal growth examinations. Uterine artery Doppler was assessed and outcome was registered from medical records.
MAIN OUTCOME MEASURES: Preeclampsia, hypertension, small-for-gestational age.
RESULTS: Serum YKL-40 was associated with increasing maternal age (p < 0.0001), body mass index (p = 0.0002), primiparity (p = 0.0003), and hypertension (p = 0.015). Serum YKL-40 increased from 12 to 20 weeks and decreased from 20-25 and 25-32 weeks of gestation. No association was found between preeclampsia and serum YKL-40. Small-for-gestational-age at birth was significantly associated with a 5.4% increase in serum YKL-40 at 32 weeks of gestation (95% CI 1.5-9.3, p = 0.005). An association was found between uterine artery pulsatility index at 32 weeks and small-for-gestational age (p = 0.0015) but not between YKL-40 and uterine artery notching (p = 0.83).
CONCLUSIONS: Serum YKL-40 was not associated with preeclampsia. Increasing serum YKL-40 was related to maternal age, body mass index and small-for-gestational age and may reflect an exaggerated inflammatory response.
Original language | English |
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Journal | Acta Obstetricia et Gynecologica Scandinavica |
Volume | 93 |
Issue number | 8 |
Pages (from-to) | 817-24 |
Number of pages | 8 |
ISSN | 0001-6349 |
DOIs | |
Publication status | Published - Aug 2014 |
- Adipokines, Adolescent, Adult, Biological Markers, Enzyme-Linked Immunosorbent Assay, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Small for Gestational Age, Lectins, Linear Models, Logistic Models, Pre-Eclampsia, Pregnancy, Prospective Studies, Pulsatile Flow, Ultrasonography, Doppler, Color, Ultrasonography, Prenatal, Uterine Artery, Young Adult
Research areas
ID: 137159714