Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease

Research output: Contribution to journalJournal articleResearchpeer-review

  • Lazlo Horvath
  • Ingrid van Marion
  • Khalid Taï
  • Troels Tolstrup Nielsen
  • Cecilia Lundberg
Dopamine depletion of the striatum is one of the hallmarks of Parkinson's disease. The loss of dopamine upregulates GAD67 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit.
Original languageEnglish
JournalThe journal of gene medicine
Volume13
Issue number3
Pages (from-to)188-97
Number of pages10
DOIs
Publication statusPublished - 1 Mar 2011

ID: 33543094