Dofetilid til patienter med hjerteinsufficiens og dårligt fungerende venstre ventrikel
Research output: Contribution to journal › Journal article › Research › peer-review
INTRODUCTION: Dofetilide, a new class III antiarrhythmic drug, was tested for its ability to reduce mortality and morbidity in patients with congestive heart failure and left ventricular dysfunction. METHODS: In 34 Danish centers, 1518 patients with NYHA class III or IV heart failure and wall motion index of the left ventricle < or = 1.2 (ejection fraction < or = 35%) were randomized to receive dofetilide or placebo in a double blind study. The dose of dofetilide was adjusted to renal function and the QT interval. Patients were monitored continuously with ekg during the first three days in the study. Minimum follow up was one year. RESULTS: Dofetilide did not affect mortality. Hospitalizations for worsening of heart failure were reduced significantly, hazard ratio 0.75 (0.63-0.89) Dofetilide effectively converted atrial fibrillation to sinus rhythm. After one year, 61% of patients with atrial fibrillation had converted on dofetilide and 33% on placebo (p < 0.001). DISCUSSION: Dofetilide can be used to convert atrial fibrillation to sinus rhythm and to maintain sinus rhythm in patients with congestive heart failure and left ventricular dysfunction. Dofetilide does not affect mortality.
Udgivelsesdato: 2000-Oct-30
Udgivelsesdato: 2000-Oct-30
Translated title of the contribution | Dofetilide to patients with heart failure and left ventricular dysfunction |
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Original language | Danish |
Journal | Ugeskrift for læger |
Volume | 162 |
Issue number | 44 |
Pages (from-to) | 5948-53 |
Number of pages | 5 |
ISSN | 0041-5782 |
Publication status | Published - 2000 |
Bibliographical note
Keywords: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cause of Death; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Ventricular Dysfunction, Left
ID: 17399130