Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester
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- Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester
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OBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of <10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss <22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).
RESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement >11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p<0.05).
CONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes.
Original language | English |
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Journal | Journal of Maternal - Fetal & Neonatal Medicine |
Volume | 27 |
Issue number | 2 |
Pages (from-to) | 149-154 |
Number of pages | 6 |
ISSN | 1476-7058 |
DOIs | |
Publication status | Published - Jan 2014 |
- Adult, Albuminuria, Blood Glucose, Congenital Abnormalities, Diabetes Mellitus, Type 1, Female, Fetal Death, Food, Gestational Age, Hemoglobin A, Glycosylated, Humans, Insulin, Insulin Aspart, Insulin, Isophane, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Third, Pregnancy in Diabetics
Research areas
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