Rapid elimination kinetics of free PSA or human kallikrein-related peptidase 2 after initiation of gonadotropin-releasing hormone-antagonist treatment of prostate cancer: potential for rapid monitoring of treatment responses
Research output: Contribution to journal › Journal article › Research › peer-review
The utility of conventional prostate-specific antigen (PSA) measurements in blood for monitoring rapid responses to treatment for prostate cancer is limited because of its slow elimination rate. Prior studies have shown that free PSA (fPSA), intact PSA (iPSA) and human kallikrein-related peptidase 2 (hK2) are eliminated more rapidly after radical prostatectomy. In contrast, all three markers have similarly slow elimination rates after castration induced by gonadotropin-releasing hormone (GnRH) agonists, possibly due to the slow onset of castration. Therefore, we assessed elimination rates of tPSA, fPSA, iPSA and hK2 after rapid induction of castration with degarelix (Firmagon(®)), a novel GnRH antagonist.
Original language | English |
---|---|
Journal | Clinical Chemistry and Laboratory Medicine |
Volume | 50 |
Issue number | 11 |
Pages (from-to) | 1993-8 |
Number of pages | 6 |
ISSN | 1434-6621 |
DOIs | |
Publication status | Published - 2012 |
ID: 48471767