Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis
Research output: Contribution to journal › Journal article › peer-review
OBJECTIVE: To investigate the effect of monthly oral methylprednisolone pulse treatment in progressive MS.
METHODS: 30 progressive MS patients were treated with oral methylprednisolone every month. Peripheral blood mononuclear cells were analyzed by flow cytometry.
RESULTS: Out of 102 leukocyte phenotypes investigated, 25 changed at nominal significance from baseline to week 12 (p<0.05). After correction for multiple comparisons, we found 5 subpopulations that changed compared to baseline. No pattern were suggesting modulation of Th17 or TFH cells.
CONCLUSION: Methylprednisolone pulse treatment has some effects on circulating immune cells but does not modulate markers of Th17 and TFH cell activity in progressive MS.
Original language | English |
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Journal | Journal of Neuroimmunology |
Volume | 276 |
Issue number | 1-2 |
Pages (from-to) | 195-201 |
Number of pages | 7 |
ISSN | 0165-5728 |
DOIs | |
Publication status | Published - 15 Nov 2014 |
- Adult, Anti-Inflammatory Agents, Female, Flow Cytometry, Humans, Leukocytes, Mononuclear, Male, Methylprednisolone, Middle Aged, Multiple Sclerosis, Severity of Illness Index
Research areas
ID: 137740406