Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project
Research output: Contribution to journal › Journal article › Research › peer-review
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality.
Original language | English |
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Journal | American Journal of Respiratory and Critical Care Medicine |
Volume | 189 |
Issue number | 6 |
Pages (from-to) | 684-696 |
Number of pages | 13 |
ISSN | 1073-449X |
DOIs | |
Publication status | Published - 15 Mar 2014 |
ID: 101683162