Concanavalin A-induced activation of lymphocytic choriomeningitis virus memory lymphocytes into specifically cytotoxic T cells
Research output: Contribution to journal › Journal article › Research › peer-review
When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.
Original language | English |
---|---|
Journal | Acta pathologica et microbiologica Scandinavica. Section C, Immunology |
Volume | 85C |
Issue number | 6 |
Pages (from-to) | 483-6 |
Number of pages | 3 |
ISSN | 0304-1328 |
Publication status | Published - 1977 |
Bibliographical note
Keywords: Animals; Concanavalin A; Cytotoxicity, Immunologic; Immunologic Memory; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C3H; Spleen; T-Lymphocytes
ID: 9702595