Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer

Research output: Contribution to journalJournal articlepeer-review

  • Stine S Korreman
  • Anders N Pedersen
  • Lasse Rye Aarup
  • Trine Juhler-Nøttrup
  • Specht, Lena
  • Håkan Nyström
  • Lasse Rye Aarup
PURPOSE: Substantial reductions of cardio-pulmonary radiation doses can be achieved using voluntary deep inspiration breath-hold (DIBH) or free breathing inspiration gating (IG) in radiotherapy after conserving surgery for breast cancer. The purpose of this study is to evaluate the radiobiological implications of such dosimetric benefits. METHODS AND MATERIALS: Patients from previously reported studies were pooled for a total of 33 patients. All patients underwent DIBH and free breathing (FB) scans, and 17 patients underwent an additional IG scan. Tangential conformal treatment plans covering the remaining breast, internal mammary, and periclavicular nodes were optimized for each scan, prescription dose 48 Gy. Normal tissue complication probabilities were calculated using the relative seriality model for the heart, and the model proposed by Burman et al. for the lung. RESULTS: Previous computed tomography studies showed that both voluntary DIBH and IG provided reduction of the lung V50 (relative volume receiving more than 50% of prescription dose) on the order of 30-40%, and a 80-90% reduction of the heart V50 for left-sided cancers. Corresponding pneumonitis probability of 28.1% (range, 0.7-95.6%) for FB could be reduced to 2.6% (range, 0.1-40.1%) for IG, and 4.3% (range, 0.1-59%) for DIBH. The cardiac mortality probability could be reduced from 4.8% (range, 0.1-23.4%) in FB to 0.5% (range, 0.1-2.6%) for IG and 0.1% (range, 0-3.0%) for DIBH. CONCLUSIONS: Remarkable potential is shown for simple voluntary DIBH and free breathing IG to reduce the risk of both cardiac mortality and pneumonitis for the common technique of adjuvant tangential breast irradiation.
Original languageEnglish
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume65
Issue number5
Pages (from-to)1375-80
Number of pages6
ISSN0360-3016
DOIs
Publication statusPublished - 1 Aug 2006

Bibliographical note

Keywords: Aged; Algorithms; Breast Neoplasms; Female; Heart; Humans; Inhalation; Lung; Middle Aged; Probability; Radiation Dosage; Radiation Injuries; Radiation Pneumonitis; Radiobiology; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Respiration

ID: 19370889