Administration of gentamicin and ampicillin by continuous intravenous infusion to newborn infants during parenteral nutrition.
Research output: Contribution to journal › Journal article › peer-review
Gentamicin and ampicillin were dissolved in an L-amino acid solution especially prepared for newborn infants and infused intravenously over 24 h in 7 babies with serious neonatal surgical problems. Serum concentrations of the antibiotics were maintained rather constant and well above the minimal inhibitory concentration for most bacterial strains. One very sick newborn infant died with overwhelming Klebsiella pneumoniae septicemia. No signs of renal toxicity or ototoxicity were found. The serum amino acids remained within the normal range, except in 1 child with cytomegalovirus infection and liver insufficiency.
Original language | English |
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Journal | Scandinavian Journal of Infectious Diseases |
Volume | 14 |
Issue number | 1 |
Pages (from-to) | 61-5 |
Number of pages | 4 |
ISSN | 0036-5548 |
Publication status | Published - 1982 |
Bibliographical note
Keywords: Amino Acids; Ampicillin; Bacterial Infections; Female; Gentamicins; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Male; Parenteral Nutrition
ID: 8670205