Administration of gentamicin and ampicillin by continuous intravenous infusion to newborn infants during parenteral nutrition.

Research output: Contribution to journalJournal articlepeer-review

  • H Colding
  • G E Andersen
Gentamicin and ampicillin were dissolved in an L-amino acid solution especially prepared for newborn infants and infused intravenously over 24 h in 7 babies with serious neonatal surgical problems. Serum concentrations of the antibiotics were maintained rather constant and well above the minimal inhibitory concentration for most bacterial strains. One very sick newborn infant died with overwhelming Klebsiella pneumoniae septicemia. No signs of renal toxicity or ototoxicity were found. The serum amino acids remained within the normal range, except in 1 child with cytomegalovirus infection and liver insufficiency.
Original languageEnglish
JournalScandinavian Journal of Infectious Diseases
Volume14
Issue number1
Pages (from-to)61-5
Number of pages4
ISSN0036-5548
Publication statusPublished - 1982

Bibliographical note

Keywords: Amino Acids; Ampicillin; Bacterial Infections; Female; Gentamicins; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Male; Parenteral Nutrition

ID: 8670205