GPCRDB: an information system for G protein-coupled receptors
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- Nucl. Acids Res.-2014-Isberg-D422-5
Final published version, 2.72 MB, PDF document
For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a 'one-stop shop' for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data, such as multiple sequence alignments and homology models. The GPCRDB also provides visualization and analysis tools, plus a number of query systems. In the latest GPCRDB release, all multiple sequence alignments, and >65,000 homology models, have been significantly improved, thanks to a recent flurry of GPCR X-ray structure data. Tools were introduced to browse X-ray structures, compare binding sites, profile similar receptors and generate amino acid conservation statistics. Snake plots and helix box diagrams can now be custom coloured (e.g. by chemical properties or mutation data) and saved as figures. A series of sequence alignment visualization tools has been added, and sequence alignments can now be created for subsets of sequences and sequence positions, and alignment statistics can be produced for any of these subsets.
Original language | English |
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Journal | Nucleic Acids Research |
Volume | 42 |
Issue number | Database issue |
Pages (from-to) | D422-D425 |
ISSN | 0305-1048 |
DOIs | |
Publication status | Published - Jan 2014 |
Bibliographical note
Funding:
Lundbeck Foundation [R54-A5441 to V.I.]; the Carlsberg
Foundation [R77-A6854 to D.G.] and the European
Union NewProt project [289350 to G.V.]. Funding for
open access charge: The publication was paid by the
CMBI running costs.
- Binding Sites, Databases, Protein, Internet, Receptors, G-Protein-Coupled, Sequence Alignment, Sequence Analysis, Protein, Software, Structural Homology, Protein
Research areas
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