Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation
Research output: Contribution to journal › Journal article › Research › peer-review
Impaired S-adenosylmethionine (SAM)-dependent transmethylation and methylation capacity feature in diseases related to obesity or aging, and selenium (Se) metabolism is altered in these states. We tested the hypothesis that SAM metabolism is required for methylation and excretion of Se in a rat model. Four hours after selenite and periodate-oxidized adenosine (POA; an inhibitor of SAM metabolism) were administered, circulating markers of single-carbon status were unchanged, except for decreased circulating phosphatidylcholine (P
Original language | English |
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Journal | Journal of Nutritional Biochemistry |
Volume | 24 |
Issue number | 12 |
Pages (from-to) | 2023-30 |
Number of pages | 8 |
ISSN | 0955-2863 |
DOIs | |
Publication status | Published - Dec 2013 |
ID: 104572974