Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils
Research output: Contribution to journal › Journal article › Research › peer-review
IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.
| Original language | English |
|---|---|
| Article number | e2149 |
| Journal | P L o S Neglected Tropical Diseases (Online) |
| Volume | 7 |
| Issue number | 3 |
| Number of pages | 8 |
| ISSN | 1935-2735 |
| DOIs | |
| Publication status | Published - 2013 |
- Adolescent, Adult, Animals, Anthelmintics, Antigens, Helminth, Child, Child, Preschool, Eosinophils, Female, Humans, Immunoglobulin E, Interleukin-5, Male, Plasma, Praziquantel, Schistosoma haematobium, Schistosomiasis haematobia, Young Adult
Research areas
ID: 65707561