The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: Circulating levels of IGF-I and IGFBP-3 are low in cirrhosis and are related to liver dysfunction. Metabolic disturbances include malnutrition with altered body composition and osteopenia. Since the effects of IGF-I may be associated to changes in body composition and bone mineral content (BMC) in cirrhotic patients, we investigated the relations between changes in the IGF-system and body composition and the effects of long-term alpha- and beta-blockade. DESIGN: The study was designed as a combined cross-sectional and prospective randomised controlled study of 62 patients with cirrhosis. Twenty-three of these patients were randomised to treatment with beta- or combined alpha/beta-blocker for 3months. Haemodynamics, body composition, and systemic and hepatic IGF-I and IGFBP-3 levels were determined in all patients. In the subgroup changes in body composition and IGF-I/IGFBP-3 levels after 3months of beta- or combined alpha/beta-blockade were additionally examined. RESULTS: Both the hepatic and the systemic IGF systems were suppressed and correlated with liver dysfunction and anthropometrics (p
Original language | English |
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Journal | Growth Hormone & I G F Research |
Volume | 22 |
Issue number | 6 |
Pages (from-to) | 212-218 |
Number of pages | 7 |
ISSN | 1096-6374 |
DOIs | |
Publication status | Published - 2012 |
ID: 48487402