Neonatal calf diarrhea (NCD) is a common disease affecting the newborn calf and the most critical period is in the first few days following birth of the calf which is also known as calf scours. Keeping animals in close confinement where the opportunity for transmission of causative agents of NCD. The diarrhea and other clinical signs seen with the disease are caused by the interaction of any of several possible infectious causes. This study was carried out to isolate, identify and detect the antimicrobial resistant profile of E. coli and Salmonella from diarrheic calves. A total of one hundred and twenty five fecal specimens were collected directly from the rectum of diarrheic calves. Of the samples collected 35 (25%) and 11 (8.8%) was found positive for E. coli and Salmonella respectively. Antimicrobial resistance of these two isolate was found against Amoxycillin and Tetracycline whereas a high sensitivity was found towards Ciprofloxacin, Levofloxacillin, Azithromycin and Cefotaxime. Serotyping was done by using specific antisera to identify variants of the somatic (O) and flagellar (H) antigens.
Cultural and biochemical features also reveal the presence of pathogens in the diarrheic calves.