TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis
Research output: Contribution to journal › Journal article › Research › peer-review
T helper (TH) 17 cells are believed to play a pivotal role in development of inflammatory bowel disease, and their contribution to intestinal inflammation has been studied in various models of colitis. TH17 cells produce a range of cytokines, some of which are potential targets for immunotherapy. However, blockade of IL-17A alone with secukinumab was not effective in Crohn's disease. In this regard, the pathogenic impact of IL-17A versus IL-17F during intestinal inflammation is still unresolved.
Original language | English |
---|---|
Journal | Inflammatory Bowel Diseases |
Volume | 19 |
Issue number | 8 |
Pages (from-to) | 1567-1576 |
Number of pages | 10 |
ISSN | 1078-0998 |
DOIs | |
Publication status | Published - 2013 |
ID: 47486081