Ultrastructure of interstitial cells in subserosa of human colon
Research output: Contribution to journal › Journal article › Research › peer-review
We studied the ultrastructure of interstitial cells in the subserosal/adventitial layer in human colon. An interstitial cell type with an ultrastructure intermediate between fibroblast-like cells (FLC) and interstitial cells of Cajal was identified (IC-SS). IC-SS had thin and flattened branching processes, most densely arranged close to the longitudinal muscle cells. Caveolae, bundles of intermediate filaments and membrane-associated dense bands, often with a patchy basal lamina, were characteristic. Secretory organelles (granular endoplasmic reticulum, smooth endoplasmic reticulum, Golgi, coated vesicles) were prominent. The IC-SS ultrastructure was different from that of FLC in the longitudinal layer, which had no caveolae and fewer intermediate filaments. Peg-and-socket junctions between IC-SS and between IC-SS and muscle cells were present, and IC-SS processes had close, selective appositions to muscle cells. Gap junctions were not observed. Small nerve bundles were abundant, but close contacts (
Original language | English |
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Journal | Cells, Tissues, Organs |
Volume | 197 |
Issue number | 4 |
Pages (from-to) | 322-32 |
Number of pages | 11 |
ISSN | 1422-6405 |
DOIs | |
Publication status | Published - 2013 |
ID: 48459326