Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity
Research output: Contribution to journal › Journal article › peer-review
ContextUnderstanding inter-subject variability in glycemic control following exercise training will help individualize treatment.ObjectiveTo determine whether this variability is related to training-induced changes in insulin sensitivity or pancreatic beta-cell function.Design, Setting, and ParticipantsAn observational clinical study of N=105 subjects with impaired glucose tolerance or type 2 diabetes.Interventions and Main Outcome MeasuresIndividual subject changes in fitness (VO2max), glycemia (HbA1c, fasting glucose, OGTT), insulin sensitivity (Si; hyperinsulinemic-euglycemic clamp), oral glucose-stimulated insulin secretion (GSIS), and disposition index (DI) were measured following 12-16-weeks of aerobic exercise training. Regression analyses were used to identify relationships between variables.ResultsFollowing training, 86% of subjects increased VO2max and lost weight. HbA1c, fasting glucose, and 2-hour OGTT glucose, were reduced in 69%, 62%, and 68% of subjects respectively; while Si improved in 90% of the participants. Changes in glycemic control were congruent with changes in GSIS such that 66% of subjects had a reduction in first-phase GSIS, and 46% had reduced second-phase GSIS. Training increased first- and second-phase DI in 83% and 74% of subjects. Training-induced changes in glycemic control were related to changes in GSIS (P
Original language | English |
---|---|
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 98 |
Issue number | 10 |
Pages (from-to) | 4176-4186 |
Number of pages | 11 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 21 Aug 2013 |
ID: 49898695