Interface mechanics and histomorphometric analysis of hydroxyapatite-coated and porous glass-ceramic implants in canine bone
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A canine study was performed to make a histological and biomechanical evaluation of the interface between bone and two different bioceramic implants. A newly developed glass-ceramic formed by P2O5, CaO, SiO2, and Al2O3, giving a crystal phase composed of CaP2O6-AlPO4-SiP2O7, was compared to hydroxyapatite (HA) coated Ti-6Al-4V implants. A total of 24 implants were inserted into the femoral condyle of 15 adult female golden retriever dogs weighing 20-25 kg. There was a 12 week follow-up. Implants were examined by mechanical testing, histology, histomorphometry, microradiograpic methods, and EDAX analysis. The ultimate shear strength for the HA-coated implants was significantly higher than in the glass-ceramic group. When these values were related to the histomorphometric measurements, the difference could be explained by the tissue-to-implant contact. The glass-ceramic showed direct contact only with nonmineralized, osteoid bone. The HA-coated implants, however, were integrated into the bone. The study indicated that porous glass-ceramic containing AlPO4 causes local osteomalacia and might not be suitable for clinical purposes.
Original language | English |
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Journal | Journal of Biomedical Materials Research |
Volume | 29 |
Issue number | 12 |
Pages (from-to) | 1477-82 |
Number of pages | 5 |
ISSN | 0021-9304 |
DOIs | |
Publication status | Published - 1995 |
Bibliographical note
Keywords: Alloys; Animals; Bone Remodeling; Bone Substitutes; Bone and Bones; Ceramics; Dogs; Female; Femur; Growth Plate; Hydroxyapatites; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Osseointegration; Prostheses and Implants; Surface Properties; Titanium
ID: 23041830