Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26±1 y) or APAP (n=8, 25±1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08±0.65 μg•ml(-1) (p0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p
Original language | English |
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Journal | Journal of Applied Physiology |
Volume | 115 |
Issue number | 6 |
Pages (from-to) | 929-936 |
Number of pages | 8 |
ISSN | 8750-7587 |
DOIs | |
Publication status | Published - 2013 |
ID: 46148542