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Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma

Research output: Research - peer-reviewJournal article

Stine D Sørensen, Tine Greve, Vera Timmermans Wielenga, W Hamish B Wallace, Claus Yding Andersen

Ewing's sarcoma (EWS) is a highly malignant cancer in children, adolescents and young adults. The chemotherapy required to treat female EWS patients may cause primary ovarian insufficiency and infertility as a side effect. Cryopreservation of ovarian tissue before the start of chemotherapy can potentially preserve fertility. When the patient has been cured and primary ovarian insufficiency has developed, transplantation of frozen/thawed ovarian tissue can restore ovarian function. The tissue is usually collected before chemotherapy is initiated, and malignant cells may contaminate the stored ovarian tissue, potentially causing recrudescence of the original cancer after transplantation. The risk of EWS metastasizing to the ovary is probably low but has not been studied in great detail. This review describes the available evidence on the risk of malignant cell contamination in the ovaries of EWS patients and presents a new case of malignant cells in an ovarian biopsy from a girl with EWS.

Original languageEnglish
JournalFuture Oncology
Volume10
Issue number2
Pages (from-to)277-283
Number of pages7
ISSN1479-6694
DOIs
StatePublished - Feb 2014

    Research areas

  • Antineoplastic Agents, Cryopreservation, Female, Humans, Infertility, Female, Neoplasm Recurrence, Local, Neoplasm Seeding, Ovarian Neoplasms, Ovary, Radiotherapy, Risk, Sarcoma, Ewing

ID: 138131321