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Neuroendocrine control of Drosophila larval light preference

Research output: Research - peer-reviewJournal article

Naoki Yamanaka, Nuria M. Romero, Francisco A. Martin, Kim Furbo Rewitz, Mu Sun, Michael B. O´Connor, Pierre Léopold

Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
Original languageEnglish
JournalScience
Volume341
Issue number6150
Pages (from-to)1113-1116
Number of pages4
ISSN0036-8075
DOIs
StatePublished - 2013

ID: 65571079