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Jonas Thue Treebak

Jonas Thue Treebak

Lektor

Medlem af:

  • Novo Nordisk Foundation Center for Basic Metabolic Research

Primære forskningsområder

  • Skeletal muscle physiology with special emphasis on the mechanisms regulating glucose and fat metabolism.
  • Involvement of NAD salvage pathways for maintaining mitochondrial function and insulin sensitivity.
  • Signaling pathways in skeletal muscle responsible for increasing insulin sensitivity in response to metabolic stress.

Udvalgte publikationer

  1. Udgivet

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O., Nielsen, R., Albrechtsen, A. & Hansen, T. 2014 I : Nature. 512, 7513, s. 190-193 4 s.

    Publikation: Forskning - fagfællebedømtLetter

  2. Udgivet

    Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 in human skeletal muscle

    Treebak, J. T., Pehmøller, C., Kristensen, J. M., Kjøbsted, R., Birk, J. B., Schjerling, P., Richter, E., Goodyear, L. J. & Wojtaszewski, J. 2014 I : Journal of Physiology. 592, 2, s. 351-375 25 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  3. Udgivet

    AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

    Brandauer, J., Vienberg, S. G., Andersen, M. A., Jørgensen, S. R., Risis, S., Larsen, P., Kristensen, J. M., Frøsig, C., Leick, L., Fentz, J., Jørgensen, S. B., Kiens, B., Wojtaszewski, J., Richter, E., Zierath, J. R., Goodyear, L. J., Pilegaard, H. & Treebak, J. T. 2013 I : Journal of Physiology. 591, s. 5207-5220 14 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  4. Udgivet

    Impairments in site-specific AS160 phosphorylation and effects of exercise training

    Consitt, L. A., Van Meter, J., Newton, C. A., Collier, D. N., Dar, M. S., Wojtaszewski, J., Treebak, J. T., Tanner, C. J. & Houmard, J. A. 2013 I : Diabetes. 62, 10, s. 3437-3447 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  5. Udgivet

    Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo

    Lauritzen, H. P. M. M., Brandauer, J., Schjerling, P., Koh, H-J., Treebak, J. T., Hirshman, M. F., Galbo, H. & Goodyear, L. J. sep. 2013 I : Diabetes. 62, 9, s. 3081-92 12 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  6. Udgivet

    Acute exercise remodels promoter methylation in human skeletal muscle

    Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J. & Zierath, J. R. 7 mar. 2012 I : Cell Metabolism. 15, 3, s. 405-11 7 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  7. Udgivet

    GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

    Biensø, R. S., Jørgensen, S. R., Kiilerich, K., Aachmann-Andersen, N. J., Krogh-Madsen, R., Guerra, B., Plomgaard, P. S., van Hall, G., Treebak, J. T., Saltin, B., Lundby, C., Calbet, J. A. L., Pilegaard, H. & Wojtaszewski, J. 2012 I : Diabetes. 61, 5, s. 1090-1099 10 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  8. Udgivet

    Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

    Vendelbo, M., Clasen, B. F. F., Treebak, J. T., Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, T. S., Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, J., Møller, N. & Jessen, N. 2012 I : American Journal of Physiology: Endocrinology and Metabolism. 302, 2, s. E190-E200 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  9. Udgivet

    Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

    Hunter, R. W., Treebak, J. T., Wojtaszewski, J. & Sakamoto, K. 2011 I : Diabetes. 60, 3, s. 766-774 9 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  10. Udgivet

    Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training

    Vind, B. F., Pehmøller, C., Treebak, J. T., Birk, J. B., Hey-Mogensen, M., Beck-Nielsen, H., Zierath, J. R., Wojtaszewski, J. & Højlund, K. 2011 I : Diabetologia. 54, 1, s. 157-167 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  11. Udgivet

    Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle

    Koh, H-J., Toyoda, T., Fujii, N., Jung, M. M., Rathod, A., Middelbeek, R. J-W., Lessard, S. J., Treebak, J. T., Tsuchihara, K., Esumi, H., Richter, E., Wojtaszewski, J., Hirshman, M. F. & Goodyear, L. J. 2010 I : Proceedings of the National Academy of Science of the United States of America. 107, 35, s. 15541-15546 6 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  12. Udgivet

    Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle

    Treebak, J. T., Taylor, E. B., Witczak, C. A., An, D., Toyoda, T., Koh, H-J., Xie, J., Feener, E. P., Wojtaszewski, J., Hirshman, M. F. & Goodyear, L. J. 2010 I : American Journal of Physiology: Cell Physiology. 298, 2, s. C377-C385 9 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  13. Udgivet

    A-769662 activates AMPK {beta}1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle

    Treebak, J. T., Birk, J. B., Hansen, B. F., Olsen, G. S. & Wojtaszewski, J. 2009 I : American Journal of Physiology: Cell Physiology. 297, 4, s. C1041-C1052 12 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  14. Udgivet

    Genetic impairment of AMPK{alpha}2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice

    Maarbjerg, S. J., Jørgensen, S. B., Rose, A. J., Jeppesen, J., Jensen, T. E., Treebak, J. T., Birk, J. B., Schjerling, P., Wojtaszewski, J. & Richter, E. 2009 I : American Journal of Physiology: Endocrinology and Metabolism. 297, 4, s. E924-E934 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  15. Udgivet

    Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmøller, C., Treebak, J. T., Birk, J. B., Chen, S., Mackintosh, C., Hardie, D. G., Richter, E. & Wojtaszewski, J. 2009 I : American Journal of Physiology: Endocrinology and Metabolism. 297, 3, s. E665-E675 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  16. Udgivet

    Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frøsig, C., Pehmøller, C., Chen, S., Maarbjerg, S. J., Brandt, N., Mackintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E., Pilegaard, H. & Wojtaszewski, J. 2009 I : Diabetologia. 52, 5, s. 891-900 10 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  17. Udgivet

    Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle

    Glund, S., Treebak, J. T., Long, Y. C., Barres, R., Viollet, B., Wojtaszewski, J. & Zierath, J. R. 2009 I : Endocrinology. 150, 2, s. 600-606 7 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  18. Udgivet

    Role of 5'AMP-activated protein kinase in skeletal muscle

    Treebak, J. T. & Wojtaszewski, J. F. P. 2008 I : International Journal of Obesity. 32 Suppl. 4, s. S13-S17 5 s.

    Publikation: ForskningReview

  19. Udgivet

    Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling

    Deshmukh, A. S., Treebak, J. T., Long, Y. C., Viollet, B., Wojtaszewski, J. F. P. & Zierath, J. R. 2008 I : Molecular Endocrinology. 22, 5, s. 1105-12 8 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  20. Udgivet

    Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment

    Højlund, K., Glintborg, D., Andersen, N. R., Birk, J. B., Treebak, J. T., Frøsig, C., Beck-Nielsen, H. & Wojtaszewski, J. F. P. 2008 I : Diabetes. 57, 2, s. 357-366 10 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  21. Udgivet
  22. Udgivet

    AS160 phosphorylation is associated with activation of alpha2beta2gamma1 - but not alpha2beta2gamma3 -AMPK trimeric complex in skeletal muscle during exercise in humans

    Treebak, J. T., Birk, J. B., Rose, A. J., Kiens, B., Richter, E. & Wojtaszewski, J. 2007 I : American Journal of Physiology: Endocrinology and Metabolism. 292, 3, s. E715-E722 8 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  23. Udgivet

    Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

    Jørgensen, S. B., Treebak, J. T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J. & Richter, E. 2007 I : American Journal of Physiology: Endocrinology and Metabolism. 292, 1, s. E331-E339 9 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  24. Udgivet

    AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits

    Treebak, J. T., Glund, S., Deshmukh, A., Klein, D. K., Long, Y. C., Jensen, T. E., Jørgensen, S. B., Viollet, B., Andersson, L., Neumann, D., Wallimann, T., Richter, E., Chibalin, A. V., Zierath, J. R. & Wojtaszewski, J. 2006 I : Diabetes. 55, 7, s. 2051-2058 8 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

ID: 7974