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Shared genetic variants suggest common pathways in allergy and autoimmune diseases

Publikation: Forskning - peer reviewTidsskriftartikel

Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H Pers, Alexessander Couto Alves, Nicole M Warrington, Carla Mt Tiesler, Elaine Fuertes, Lude Franke, Joel N Hirschhorn, Alan James, Angela Simpson, Joyce Y Tung, Gerard H Koppelman, Dirkje S Postma, Craig E Pennell, Marjo-Riitta Jarvelin, Adnan Custovic, Nicholas Timpson & 6 andre Manuel A Ferreira, David P Strachan, John Henderson, David Hinds, Hans Bisgaard, Klaus Bønnelykke

BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood.

OBJECTIVE: To investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms.

METHODS: We meta-analyzed two GWAS on self-reported allergy and sensitization comprising a total of 62,330 individuals. These results were used to calculate enrichment for SNPs previously associated with autoimmune diseases. Furthermore, we probed for enrichment within genetic pathways and of transcription factor binding sites, and characterized commonalities in the variant burden on tissue-specific regulatory sites by calculating the enrichment of allergy SNPs falling in gene regulatory regions in various cells using Encode Roadmap DHS data, and compared the allergy data with all known diseases.

RESULTS: Among 290 loci previously associated with 16 autoimmune diseases, we found a significant enrichment of loci also associated with allergy (p=1.4e-17) encompassing 29 loci at a false discovery rate<0.05. Such enrichment seemed to be a general characteristic for all autoimmune diseases. Among the common loci, 48% had the same direction of effect for allergy and autoimmune diseases. Additionally, we observed an enrichment of allergy SNPs falling within immune pathways and regions of chromatin accessible in immune cells that was also represented in autoimmune diseases, but not in other diseases.

CONCLUSION: We identified shared susceptibility loci and commonalities in pathways between allergy and autoimmune diseases, suggesting shared diseases mechanisms. Further studies of these shared genetic mechanisms might help understanding the complex relationship between these diseases, including the parallel increase in disease prevalence.

OriginalsprogEngelsk
TidsskriftThe Journal of allergy and clinical immunology
Vol/bind140
Tidsskriftsnummer3
Sider (fra-til)771-781
ISSN0091-6749
DOI
StatusUdgivet - 7 feb. 2017

ID: 174400961