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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

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  • Lund2013

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Michael Taulo Lund, Lærke Taudorf, Bolette Hartmann, Jørn Wulff Helge, Jens Juul Holst, Flemming Dela

Postprandial insulin release is lower in healthy
aerobically trained (T) compared to untrained (UT) individuals.
This may be mediated by a lower release of the
two incretin hormones [glucagon like peptide-1 (GLP-1)
and glucose-dependent insulinotropic polypeptide (GIP)] in
T. The aim of this study was to assess and compare gut
hormone response and satiety changes after a liquid meal
intake in young, healthy T and UT males. Postprandial gut
hormone release and subjective feelings of hunger, satiety,
fullness and prospective food consumption were assessed
before and frequently for the following 3 h after a 200 ml
liquid meal (1,260 kJ and 27, 41 and 32 energy % as
protein, carbohydrates and fat, respectively) in ten T and
ten UT young, healthy male subjects. The insulin and GIP
responses were markedly lower in T than UT and correlated
during the first 30 min after the liquid meal. Baseline
GLP-1 concentration was higher in T versus UT, but the
response in the following 3 h after a liquid meal was
similar in T and UT. Satiety measures did not differ
between groups throughout the test. It is possible that in
aerobically T subjects, a lower GIP release is partly
responsible for a lower postprandial incretin stimulated
insulin secretion.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Applied Physiology
Vol/bind113
Tidsskriftsnummer11
Sider (fra-til)2737-47
Antal sider11
ISSN1439-6319
DOI
StatusUdgivet - 1 nov. 2013

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