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Ulla M. Wewer

Ulla M. Wewer

Dekan


Curriculum Vitae
Ulla Margrethe Wewer, Professor, DMSc and Dean
Faculty of Health Sciences, University of Copenhagen
Blegdamsvej 3B, 2200 Copenhagen, Denmark
Telephone: +45 35327051; cell phone  + 45 28757051
E-mail: ullaw@sund.ku.dk

Nationality: Danish
Date of Birth:  December 7, 1953 (married, one son 21 yr)

Education and Degrees
1980:  Medical Doctor, University of Copenhagen
1985:  Doctor of Medical Sciences, University of Copenhagen

Academic Employment
1980-1983: Various positions at clinical departments
1984-1987: Research positions at NIH, Bethesda, USA
1986-1999: Assistant and associate professor at the Institute of Molecular Pathology at University of Copenhagen
1999: Research professor sponsored by the Neye-Foundation and The Danish Medical Research Council, at the University of Copenhagen 
Since 2000: Permanent professor in Experimental Pathology at the University of Copenhagen 

Administrative ativities and employment
2002-06: Vice-dean at the Faculty of Health Sciences
Since 2006: Dean of the Faculty of Health Sciences, University of Copenhagen

Teaching and Supervision
Pathology for medical students, dental students, and human biologists
Supervisor of undergraduate and graduate students

Referee and invited speaker
Offical opponent for PhD and Doctor of Medical Sciences thesis
Referee for several international journals and grant agencies, including Netherlands Cancer Foundation, Human Frontier Science Program, The Deutsche Forschungsgemeinschaft (DFG), Medical Research Council in London, Welcome Trust in UK.
Invited speaker at several international meetings and seminars.

Research activities and honors
Published about 120 original peer-reviewed papers and some 25 reviews and other publications. For many years, I have been studying the structure and function of the extracellular matrix, cell-matrix interactions, and cell adhesion proteins, particularly as they relate to cancer.

I have received several honors, including:

  • The Experimental Pathologists in Training Award (1986) by the American Association of Pathologists, USA
  • Odd Fellow Ordenens Research Prize 1987
  • The Young Investigators Research Award (1993) by the Danish Cancer Society
  • The August Krogh Prize (2002)
  • Tagea Brandts Rejselegat (2010). 

I carry an elected membership in the Royal Danish Academy of Sciences and Letters. 

List of publications

(15 selected publications) by Ulla M Wewer

1. Wewer U, Albrechtsen R, Manthorpe M, Varon S, Engvall E. and Ruoslahti E: Human laminin isolated in a nearly intact, biologically active form from placenta by limited proteolysis. J Biol Chem 258: 12654-12660, 1983

2. Wewer UM, Liotta LA, Jaye M, Ricca GA, Drohan WN, Claysmith AP, Rao CN, Wirth P, Coligan JE, Albrechtsen R, Mudryj M, Sobel ME: Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci USA 83: 7137-7141, 1986

3. Xu H, Wu X-R, Wewer UM, Engvall E. Murine muscular dystrophy caused by a mutation in the laminin a2 (Lama2) gene. Nature Genetics 8:297-302, 1994

4. Gilpin BJ, Loechel F, Mattei M-G, Engvall E, Albrechtsen R, Wewer UM. A novel secreted form of human ADAM 12 (meltrin a) provokes myogenesis in vivo. J Biol Chem 273:157-166, 1998

5. Iba K, Albrechtsen R, Gilpin B, Fröhlich C, Loechel F, Zolkiewska A, Ishiguro K, Kojima T, Liu W, Langford JK, Sanderson RD, Brakebusch C, Fässler R, Wewer UM. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and trigggers signaling events that lead to b1 integrin-dependent cell spreading. J Cell Biol 149: 1143-1155, 2000

6. Kawaguchi N, Sundberg S, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Möller P, Mercurio AM, Albrechtsen R, Wewer UM. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating b1 integrin function. J Cell Sci 116:3893-3904, 2003

7. Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, and Wewer UM. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res 65:4754-61, 2005

8. Wewer UM, Morgelin M, Holck, Jacobsen J, Lydoph MC, Johnsen AH, Kveiborg M, Albrechtsen R. ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme. J Biol Chem 281:9418-22, 2006

9. Fröhlich C, Albrechtsen R, Dyrskjøt L, Rudkjær L, Ørntoft TF, Wewer UM. Molecular profiling of ADAM12 in human bladder cancer: ADAM12 correlates with disease status and is increased in the urine. Clin Cancer Res 12:7359-68, 2006

10. Sørensen HP, Vives R, Manetopoulos C, Albrechtsen R, Lydolph M, Jacobsen J, Couchman JR, Wewer UM. Heparan sulphate regulates the proteolytic activity of ADAM12 through a specific molecular switch in the pro domain. J Biol Chem 283: 31920-32, 2008

11. Stautz D, Sanjay A, Hansen MT, Albrechtsen R, Wewer UM, Kveiborg M. ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity. Exp Cell Res 316:55-67, 2010

12. Kveiborg M, Jacobsen J, Lee MH, Nagase H, Wewer UM, Murphy G. Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinases (TIMP)-2. Biochem J 430:79-86, 2010  

13. Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer UM. Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity. Exp Cell Res 317:195-209, 2011

14. Fröhlich, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M Sehara-Fijisawa A, Mercurio AM, Wewer UM. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res 9:1449-61, 2011

15. Yoneda A, Morgan-Fisher M, Wait R, Couchman JR, Wewer UM. A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II. Mol Cell Biol 32:1788-804, 2012 

Uddannelse

professor, dr. med.

ID: 914939