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Thomas Skov

Thomas Skov


  • Chemometrics and Analytical Technology

    Rolighedsvej 26

    1958 Frederiksberg C

    Telefon: +45 35 33 37 39Mobil: +45 21 28 91 24

Conditions of employment

07/2011-                  Associate Professor at Spectroscopy and Chemometrics – SPECC (formerly Quality & Technology), Department of Food Science, University of Copenhagen (SCIENCE), Denmark

05/2009-06/2011     Assistant Professor at Quality & Technology, Department of Food Science, University of Copenhagen (KU-LIFE), Denmark

11/2008-04/2009     Post Doc at Quality & Technology, Department of Food Science, University of Copenhagen (KU-LIFE), Denmark

09/2008-11/2008     Post Doc at the National Food Institute, Danish Technical University (DTU), Denmark

05/2008-09/2008     Research Assistant at the National Food Institute, Danish Technical University (DTU), Denmark

01/2005-06/2008     FOOD PhD-student at Quality & Technology, Department of Food Science, University of Copenhagen (KU-LIFE), Denmark

10/2006-10/2007     Chemometrics Consultant, Nuevolution A/S, Copenhagen, Denmark

Research awards

06/2014      Awarded by His Royal Highness The Prince's Foundation for individuals who have increased the prestige of Denmark in research.


2005-2008       PhD from Quality & Technology, Department of Food Science, University of Copenhagen, Denmark (Thesis entitled: ‘Mathematical resolution of complex chromatographic measurements’)

1999-2003       Master of Food Science, The Royal Veterinary and Agricultural University, KVL, Denmark (name changed to University of Copenhagen the 1st of January 2007)

1996-1999       Bachelor of Food Science, The Royal Veterinary and Agricultural University, KVL, Denmark

Publications (peer-reviewed)

Publication summary (per April 2015)

Researcher ID: B-8733-2014

H-index: 13 (Google Scholar)

Scientific peer-reviewed papers: 42

Number of citations in total: 801 (Google Scholar)

Best cited papers (per February 2015): 1) Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age: 165 citations; 2) Automated alignment of chromatographic data: 158 citations.

[41] CE Eskildsen, Morten Arendt Rasmussen, Søren Balling Engelsen, Lotte Bach Larsen, Nina Aagaard Poulsen, Thomas Skov. Journal Quantification of individual fatty acids in bovine milk by infrared spectroscopy and chemometrics: Understanding predictions of highly collinear reference variables. Journal of dairy science 2015: 97 (12), 7940-7951

[40] MB Gholivand, AR Jalalvand, HC Goicoechea, G Paimard, T Skov. Surface exploration of a room-temperature ionic liquid-chitin composite film decorated with electrochemically deposited PdFeNi trimetallic alloy nanoparticles by pattern recognition: An elegant approach to developing a novel biotin biosensor. Talanta 2015: 131, 249-258

[39] SD Aunsbjerg, AH Honoré, J Marcussen, P Ebrahimi, FK Vogensen, C Benfeldt, T Skov, S Knøchel. Contribution of volatiles to the antifungal effect of Lactobacillus paracasei in defined medium and yogurt. International journal of food microbiology 2015: 194, 46-53

[38] Carina Svendsen, Thomas Skov, Frans van den Berg, Monitoring fermentation processes using in-process measurements of different orders. Journal of chemical technology and biotechnology 2015: 90 (2), 244-254

[37] Mohammad-Bagher Gholivand, Ali R. Jalalvand, Hector C. Goicoeche , Raimundo Gargallo, Thomas Skov; Chemometrics: An important tool for monitoring interactions of vitamin B7 with bovine serum albumin with the aim of developing an efficient biosensing system for the analysis of protein. Accepted for publication in Talanta. 2014

[36] Mohammad-Bagher Gholivand, Ali R Jalalvand, Giti Paimard, Hector C Goicoechea, Thomas Skov, Reza Farhadi, Sirous Ghobadi, Nozar Moradi, Vahid Nasirian. Fabrication of a novel naltrexone biosensor based on a computationally engineered nanobiocomposite. In press in International Journal of Biological Macromolecules

[35] Søren Furbo, Asger B. Hansen, Thomas Skov, and Jan H. Christensen. Pixel-Based Analysis of Comprehensive Two-Dimensional Gas Chromatograms (Color Plots) of Petroleum: A Tutorial. Analytical Chemistry 2014 86 (15), 7160-7170

[34] M. Martínez Vega, C. Varming, T. Skov & T.B. Toldam-Andersen. Post-harvest ripening increase cultivar specific sensory and analytical aroma profile in apple juice: A study of four commercial cultivars in Denmark. Acta Agriculturae Scandinavica, Section B — Soil & Plant Science Volume 64, Issue 3 pages 244-251, 2014. DOI:10.1080/09064710.2014.905622

[33] Henrik M Roager, Karolina Sulek, Kasper Skov, Henrik L Frandsen, Jørn Smedsgaard, Andrea Wilcks, Thomas H Skov, Silas G Villas-Boas, Tine R Licht. Lactobacillus acidophilus NCFM affects vitamin E acetate metabolism and intestinal bile acid signature in monocolonized mice. Gut Microbes 5:3, 1–8; May/June 2014

[32] Karolina Sulek, Louise Kristine Vigsnaes, Line Rieck Schmidt, Jesper Holck, Henrik Lauritz Frandsen, Jørn Smedsgaard, Thomas Hjort Skov, Anne S. Meyer, Tine Rask Licht. A combined metabolomic and phylogenetic study reveals putatively prebiotic effects of high molecular weight arabino-oligosaccharides when assessed by in vitro fermentation in bacterial communities derived from humans. Anaerobe. Volume 28, August 2014, Pages 68–77

[31] Mohammad-Bagher Gholivand, Ali R. Jalalvand, Hector C. Goicoechea, Thomas Skov. Fabrication of an ultrasensitive impedimetric buprenorphine hydrochloride biosensor from computational and experimental angles. Talanta, Volume 124, 15 June 2014, Pages 27–35

[30] Thomas Skov, Anders H. Honoré, Henrik Max Jensen, Tormod Næs, Søren B. Engelsen. Chemometrics in foodomics: Handling data structures from multiple analytical platforms. TrAC Trends in Analytical Chemistry. Volume 60, September 2014, Pages 71–79

[29] Mohammad-Bagher Gholivand, Ali R Jalalvand, Hector C Goicoechea, Raimundo Gargallo, Thomas Skov, Giti Paimard. Combination of electrochemistry with chemometrics to introduce an efficient analytical method for simultaneous quantification of five opium alkaloids in complex matrices. Talanta 2015: 131, 26-37

[28] Anders Bergström, Thomas Hjort Skov, Martin Iain Bahl, Henrik Munch Roager, Line Brinch Christensen, Katrine Tschentscher Ejlerskov, Christian Mølgaard, Kim F. Michaelsen, and Tine Rask Licht. Establishment of intestinal microbiota during early life: A longitudinal, explorative study of a large cohort of Danish infants. Appl. Environ. Microbiol. AEM.00342-14; published ahead of print 28 February 2014, doi:10.1128/AEM.00342-14

[27] MB Gholivand, AR Jalalvand, HC Goicoechea, T Skov. Chemometrics-assisted simultaneous voltammetric determination of ascorbic acid, uric acid, dopamine and nitrite: Application of non-bilinear voltammetric data for exploiting first-order advantage, Talanta, 2014, 119, 553-563

[26] LG Johnsen, JM Amigo, T Skov, R Bro. Automated resolution of overlapping peaks in chromatographic data, Journal of Chemometrics, 2013. DOI: 10.1002/cem.2575

[25] S Favalli, T Skov, C Spence, DV Byrne. Do you say it like you eat it? The sound symbolism of food names and its role in the multisensory product experience, Food Research International 54 (1), 760-771.

[24] AH Honoré, M Thorsen, T Skov. Liquid chromatography–mass spectrometry for metabolic footprinting of co-cultures of lactic and propionic acid bacteria, Analytical and bioanalytical chemistry 405 (25), 8151-8170.

[23] Lea Gioertz Johnsen, Thomas Skov, Ulf Houlberg and Rasmus Bro. An automated method for baseline correction, peak finding and peak grouping of chromatographic data. Analyst 2013, 138(12): 3502-11.

[22] Sara Favalli, Thomas Skov and Derek V. Byrne. Sensory perception and understanding of food uniqueness: from the traditional to the novel. Food Research International 2013, 50(1): 176-188.

[21] Camilla Varming, Mikael Agerlin Petersen, Thomas Skov and Ylva Ardö. Challenges in quantative analysis of aroma compounds in cheeses with different fat content and maturity level. International Dairy Journal, 29 (1): 15-20.

[20] Mabel V. Martínez Vega, Sara  Sharifzadeh,  Dvoralai Wulfsohn,   Thomas Skov,  Line Harder Clemmensen, Torben Toldam- Andersen. A sampling approach for the eating quality prediction of apples using VIS-NIR spectroscopy. Journal of the Science of Food and Agriculture. 2013 Apr 30. doi: 10.1002/jsfa.6207.

[19] Mette Marie Løkke, Helene Fast Seefeldt, Thomas Skov, Merete Edelenbos. Color and textural quality of packaged wild rocket measured by multispectral imaging. Postharvest Biology and Technology 2013, 75: 86–95.

[18] Murphy, K. R.; Wenig, P.; Parcsi, G.; Skov, T.; Stuetz, R. M., Characterizing odorous emissions using new software for identifying peaks in chemometric models of gas chromatography–mass spectrometry datasets. Chemom. Intell. Lab. 2012, 118:41-50.

[17] Hanhineva K, Aura A-M, Rogachev I, Matero S, Skov T, Aharoni A, Poutanen K, Mykkänen H. In vitro microbiotic fermentation causes an extensive metabolite turnover of rye bran phytochemical. PLoS ONE 2012, 7(6): 1-10.

[16] Gözde Gürdeniz, Mette Kristensen, Thomas Skov, Rasmus Bro, Lars O. Dragsted. The effect of LC-MS data preprocessing methods on the selection of plasma biomarkers in fed vs. fasted rats. Metabolites. Metabolites 2012, 2: 77-99.

[15] Birgitte Smith, Susan Bodé, Thomas Hjort Skov, Hengameh Mirsepasi, Gorm Greisen, Karen A Krogfelt. (2012). Investigation of the early intestinal microflora in premature infants with/without necrotizing enterocolitis using two different methods. Pediatric Research, 71 (1): 115–120.

[14] Holse, M., Skov, T. & Hansen, Å. (2011) Oxidative stability of roasted marama beans (Tylosema esculentum) during storage. Food Research International. doi:10.1016/ j.foodres.2011.10.027.

[13] Karolina Sulek, Henrik Lauritz Frandsen, Jørn Smedsgaard, Thomas Hjort Skov, Naseer Mahmoud Shukri, Andrea Wilcks & Tine Rask Licht. Metabolic footprint of Lactobacillus acidophilus NCFM at different pH. Metabolomics. Online First™, 9 April 2011. DOI: 10.1007/s11306-011-0305-4.

[12] E. S. Holm, A. Schäfer, T. Skov, A.G. Koch & M.A. Petersen. (2012) Identification of chemical markers for the sensory shelf-life of saveloy. Meat Science, 90 (2): 314-322.

[11] Hans Bisgaard; Nan Li; Klaus Bonnelykke; Bo Lund Krogsgaard Chawes; Thomas Skov; Georg Paludan-Müller; Jakob Stokholm; Birgitte Smith & Karen Angeliki Krogfelt. (2011). Reduced Diversity of the Intestinal Microbiota during Infancy is Associated with Increased Risk of Allergic Disease at School Age. Journal of Allergy and Clinical Immunology, 128 (3): 646-652.

[10] Amigo, J.M., Skov, T. and Bro, R. (2010) ChroMATHography: Solving Chromatographic Issues with Mathematical Models and Intuitive Graphics. Chemical Reviews, 110: 4582–4605.

[9] Hausner, H, Philipsen, M, Skov, T, Petersen, M.A. and Bredie, W.L.P. (2009) Characterization of the Volatile Composition and Variations Between Infant Formulas and Mother’s Milk. Chemosensory Perception, 2 (2): 79-93.

[8] Skov, T., Hoggard, J.C., Bro, R. and Synovec, R.E. (2009) Handling Within Run Retention Time Shifts in Two-Dimensional Chromatography Data using Shift Correction and Modeling. Journal of Chromatography A 1216 (18): 4020-4029.

[7] Ballabio, D., Skov, T., Leardi, R. and Bro, R. (2008) Classification of GC-MS measurements of wines by combining data dimension reduction and variable selection techniques. Journal of Chemometrics, 22: 457–463.

[6] Amigo, J.M., Skov, T., Coello, J., Maspoch, J., and Bro, R. (2008) Solving GC-MS problems with PARAFAC2. Trends in Analytical Chemistry – TrAC, 27 (8): 714-725.

[5] Skov, T, Balabio, D. and Bro R. (2008) Multiblock Variance Partitioning. A new approach for comparing variation in multiple data blocks. Analytica Chimica Acta, 615 (1): 18-29.

[4] Skov, T. and Bro, R. (2008) Solving fundamental problems in chromatographic analysis, Analytical and Bioanalytical Chemistry, 390 (1): 281-285.

[3] Skov T, van den Berg, F., Tomasi, G., Bro, R. (2006) Automated alignment of chromatographic data, Journal of Chemometrics, 20 (11-12): 484-497.

[2] Bro, R., Brockhoff, P.M.B. and Skov, T. (2006) Challenges for data analysis in flavour science. Flavor Science: Recent Advances and Trends.  W. L. P. Bredie and M. A. Petersen (Eds). Elsevier, 619-621, 2006.

[1] Skov, T. and Bro, R. (2005) A new approach for modelling sensor based data. Sensors and Actuators B: Chemical, vol. 106 (2) 2005: 719-729.

Publications (public dissemination)

[E] Thomas Skov, Søren Balling Engelsen, Rasmus Bro and Lars Nørgaard (2010) Tiderne skifter. Dansk Kemi, vol. 9, 00. 58-59.

[D] Thomas Skov, Rasmus Bro and Birger Pedersen (2009) Matematisk Kromatografi. Dansk Kemi, vol. 9, pp. 18-20.

[C] Karin Kjeldahl, Thomas Skov, Søren Balling Engelsen, Rasmus Bro and Lars Nørgaard (2009) Bestemmelse af dioxin i fiskemel ud fra fedtsyresammensætningen. Dansk Kemi, vol. 6/7, pp. 28-29.

[B] Thomas Skov, Karin Kjeldahl, Søren Balling Engelsen, Rasmus Bro and Lars Nørgaard (2009). Eksplorativ evaluering af samspillet mellem dioxin og fede syrer i fiskemel. Dansk Kemi, vol. 5, pp. 40-41.

[A] Lars Nørgaard, Søren Balling Engelsen, Rasmus Bro and Thomas Skov (2008) Outliers i Principal Component Analysis - fokus på individet. Dansk Kemi, vol. 8, pp. 15-16.

Book chapters

Skov, T & Engelsen, S.B. (2013). Chapter 19:  CHEMOMETRICS, MASS SPECTROMETRY, AND FOODOMICS. In Foodomics: Advanced Mass Spectrometry in Modern Food Science and Nutrition. John Wiley & Sons, Inc. All rights reserved. Editor(s): Alejandro Cifuentes, DOI: 10.1002/9781118537282

Åsmund Rinnan, Jose Manuel Amigo and Thomas Skov, Chapter 9: Multiway methods in food science. In Mathematical and Statistical Methods in Food Science and Technology.

Teaching and supervision

Supervision, MSc students: 8 (finished and on-going). Examples: 1. Optimization of laboratory scale brewing fermentation using spectroscopy and other fast methods; 2. Innovation in the food sector with PAT - Investigation of a knowledge broker as a driver for improvement of absorptive capacity

Supervision, PhD students: 7 (finished and on-going). Examples: 1. Fermentation and Separation Monitoring, 2. High-throughput FT-IR-based solutions for economically important milk quality characteristics

More than 10 MSc and PhD courses in Denmark and worldwide. Examples: 1. ‘Data Mining and Visualization’ at the Copenhagen University College of Engineering, Ballerup, 2. course ‘Exploratory Data Analysis/Chemometrics’ at SCIENCE  

PhD students

Supervision of PhD students (finished)

-       Karolina Sulek (DTU-FOOD) – pre-biotics, metabolomics (LC-MS) and microbiota (DGGE)

-       Lea Giørtz Johnsen (IFV, KU-LIFE / Chr. Hansen) – fermentations and chemometrics (GC-MS)

-       Gözde Gürdeniz (IFV/IHE, KU-LIFE) – metabolomics (LC-MS)

-       Søren Furbo Skødt Nielsen (IGM, KU-LIFE) – chromatography and data modeling (GC×GC-ToFMS)

Supervision of PhD students (on-going)

-       Carina Svendsen (IFV, SCIENCE, KU) BIOPRO – biotechnological production

-       Anders Honore (IFV, KU-LIFE / Dupont (Danisco)) – metabolomics (LC-MS)

-       Carl Emil Aae Eskildsen (IFV, inspire) – High-throughput FT-IR-based solutions for economically important milk quality characteristics

Master students

Supervision of Master students (finished)

-       Carl Emil Aae Eskildsen (see above)

-       Majken Andersen (PAT and innovation)

-       Pernille Schrøder Andersen (Why do some liquorice pastilles turn grey?)

-       Mia Philipsen (Aroma Compounds in Mother’s Milk and Infant Formulas)

-       Kamilla Christensen (Development of flavours and oxidation products in dry fermented sausages - Influence of various antioxidants and starter cultures)

-       Jannie Sze Silfverberg (Quality indexing for lightly preserved meat products)

Supervision of Master students (on-going)

-       Mai Stahl Madsen (Carlsberg, beer and PAT)

-       Trine Johnsen (Chr. Hansen, microbiology)




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