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Lars Ove Dragsted

Lars Ove Dragsted

Sektionsleder, professor

Research fields Bioactive compounds in food with an ability to prevent or alter the risk of life style disease. Early nutrition-related studies are focused on health effects of fruit, vegetables and on organoselenium compounds. More recent work is focusing on the development and application of biomarkers for intake also of other specific kinds of food and for their effects on health. The establishment of an LC-MS based metabolomics platform and an experimental bio-bank has had particular focus in the last years.

Markers are applied primarily in human studies, including dietary intervention studies, environmental studies and biobank-based cohort studies.

Other tasks Graduate and post-graduate teaching of students in areas of nutrition, metabolomics biochemistry, and toxicology related to bioactive food components.

 

Aktuel forskning

Current and recent projects

Biomarkers of Food intake is a Marie Sklodowska Curie postdoc grant running 2017-2018 for Rastislav Monosic to develop quantitative food intake biomarkers.

MACH15 is a study supported by the NIH foundation on effects of one drink a day or abstention from alcohol on the risk of cardiovascular disease and diabetes.The study is planned to start recruiting in 2018 and to commence until 2024.

Biomarker development  for Dietary Trials This project is supported by a prestigeous Semper Ardens grant from the Carlsberg Foundation to develop novel methods for assessing compliance in large human trials as well as biochemical and cognitive effects of low level intakes of foods and drinks.

MetAl, Metabolic effects of Alcohol, is a post-doc project for Rastislav Monosik funded by the Carlsberg Foundation running 2015-2016. The aim is to set up a panel of biomarkers for alcohol intake and early biological effects and for intake of alcohol containing beverages covering different absorption and excretion kinetics. The purpose is to be able to use these markers with a variety of human samples to provide a tool for different sciences, where alcohol use and abuse are of interest, including health and social sciences, and humanities.

FoodBAll, the Food Biomarker Alliance, is an activity under the Bio-NH call of the Joint Programming Initiative, A Healthy Diet for a Healthy Life, was launched in December 2014 for a 3½-year period, during which each partner is funded by their country-specific strategic research councils. Lars O. Dragsted is a Danish partner and WP leader. The background is that dietary assessment methods are currently subjective and better tools are needed to improve the quality of nutritional studies. FoodBAll aims to identify, validate and organize food intake and nutrient biomarkers for use in nutrition research. The primary tool for identifying new biomarkers of intake is untargeted metabolomics. The research in food intake biomarkers has recently been reviewed.

ENPADASI, Data Sharing Initiative, is an activity under the ENPADASI call of the Joint Programming Initiative, A Healthy Diet for a Healthy Life, was launched in December 2014 for a 2½-year period, during which each partner is funded by their country-specific strategic research councils. Lars O. Dragsted is a Danish partner and WP leader. The background is that a large number of publicly funded studies in nutrition result in useful data beyond their primary purpose and this data can and should be shared more broadly between researchers, however databases for this purpose are not available. The consortium will set up a nutritional study database where is will be possible to share data from partner studies. The purpose is to set up a prototype database, include a number of partner studies and showcase the potentials of better data sharing between research groups in Europe or even across the world.

PREVIEW, Prevention of diabetes through lifestyle Intervention and population studies in Europe and around the World, is an European research integrated project funded under FP7 and launched in Jan 2013. It includes a 3-year multicentre study on the effects of a high-protein, low GI diet on diabetes. The project is coordinated by Anne Raben, NEXS. Our role is to investigate biomarkers of compliance, of dietary effects and biomarkers potentially related to colon cancer risk.

Metabeer, Metabolomics of Beer intake, is a study coordinated by Lars Ove Dragsted and launched in December 2012 to investigate potential intake biomarkers of beer intake based on a meal trial. The project is funded by the Carlsberg Breweries.

Mulige interessekonflikter

Lars Ove Dragsted fungerer som konsulent for Steno Diabetes Center i Gentofte med henblik på midlertidig ledelse af gruppen for Systemmedicin.

Lars Ove Dragsted har i øvrigt ingen konsulentopgaver for virksomheder eller organisationer og har ingen direkte økonomiske interesser i nogen virksomhed indenfor fødevarer.

Lars Ove Dragsted har forskningssamarbejde financieret af offentlige og private fonde eller virksomheder; samarbejde med offentlige eller private virksomheder er en forudsætning for at kunne søge strategiske forskningsmidler i Danmark.

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